diff --git a/gnu/packages/valgrind.scm b/gnu/packages/valgrind.scm
index 82e3b80f7f85374dba442213f9c8d36e2bb789e9..44a83812354dc960b9e4be9de168db99ccbba286 100644
--- a/gnu/packages/valgrind.scm
+++ b/gnu/packages/valgrind.scm
@@ -60,4 +60,8 @@ (define-public valgrind
 tools.  There are Valgrind tools that can automatically detect many memory
 management and threading bugs, and profile your programs in detail. You can
 also use Valgrind to build new tools.")
-    (license gpl2+)))
+    (license gpl2+)
+
+    ;; Building VEX on mips64el-linux fails with "opcode not supported on this
+    ;; processor: mips3".
+    (supported-systems (delete "mips64el-linux" %supported-systems))))